10 countries that take Hydroxychloroquine as first defense against the corona virus has a death rate of one third compared to the rest of the world, and recoveries are faster too.

Washington (CNN)Dr. Anthony Fauci said Wednesday that data shows hydroxychloroquine is not an effective treatment for the coronavirus, disputing use of the drug to fight the deadly virus even as President Donald Trump touts it as a potential cure and says he has taken it himself.

“The scientific data is really quite evident now about the lack of efficacy for it,” Fauci, a key medical adviser on the White House coronavirus task force, told CNN’s Jim Sciutto on “Newsroom” of the drug, adding that there’s likelihood of “adverse events with regard to cardiovascular.”
Dr Fauci, how do you explain the excellent results in more than 10 countries, where HCQ  is taken (Sometimes together with Azithromycine and sometimes with added Zinc) as soon as COVID-19 symptoms shows up, sometimes before a positive test is confirmed?

This is a very interesting chart:

But wait. Not so fast. These countries may have a younger population, and the death rate is much lower for younger people. This chart tells the relative death rate, and it shows that with the advent of the coronavirus the death risk doubled regardless of the age of the victim.

The death rate doubles for every 8 years as you age or about 9% per year. The world median age is 30.4 years. So let the world death rate be the norm

World death rate as of May 21 is 6.42% of diagnosed cases. and recovered cases versus deaths is 7.05

Compare this with 10 countries that use HCQ for most patients as soo as they test positive for the corona virus.

Turkey: Death rate 2.84%, median age 30.9, adjusted death rate 2.72%, recovered cases versus deaths  27.7

South Korea: Death rate 2.37%, median age 30.9, adjusted death rate 2.26% recovered cases versus deaths  38.4

Malaysia: Death rate 1.51%, median age 28.5, adjusted death rate 1.74% recovered cases versus deaths  53.6

Senegal: Death rate 1.16%, median age 18.8, adjusted death rate 3.10%, recovered cases versus deaths  43.2

Costa Rica: Death rate 1.02%, median age 31.3, adjusted death rate 0.95%, recovered cases versus deaths  63.9

United Arab emirates: Death rate 0.80%, median age 30.9, adjusted death rate  0.77%, recovered cases versus deaths  64.7

Bahrain: Death rate 1.50%, median age 32.3, adjusted death rate 1.30%, recovered cases versus deaths  353.0

Morocco: Death rate 2.65%, median age 29.3, adjusted death rate 2.88%, recovered cases versus deaths  25.3

Russia: Death rate 1.00%, median age 30.9, adjusted death rate 0.95%, recovered cases versus deaths  36.5

Qatar: Death rate 0.07%, median age 30.9, but since 88% of the population are migrant workers between 20 and 60, the adjusted death rate is at least 8 times higher, or 0.56 %, and recovered cases versus deaths  466.3

Taking the average, not adjusted for the size of the populations we get the average adjusted death rate for countries, where people are taking HCQ + Zinc when diagnosed positive, is 1.89%.

This means that the risk of death is reduced by a factor of 3.4 if HZQ + Zinc is taken as early as possible after a positive diagnosis for coronavirus!

Recovered cases versus deaths is an indicator of how fast patients recover after taking HCQ. Taking the arithmetic average would be unfair, so here I show the median recovery ratio, or about 40, compared to the recovery rate for the rest of the world of 7.05, an improvement of 5.6 times as many earlier recoveries.

What are we waiting for, and what is your concern, Dr Fauci? Hydroxychloroquine is approved for Malaria, Lupus and Rheumatoid Arthritis, and is used by millions or people world wide with normal precautions. There are side-effects, but death is not one listed, and the cardiac concern is taken care of with a simple ECG, disqualifying less than 1% of the patients.

WHO paused a double blind study out of an “abundance of caution”.

Is HCQ too cheap to promote?

I for one want to save lives.

 

Make a nationwide clinical test of using the combination Hydroxychloroquine + Azithromycin + Zinc for five days to treat COVID-19 patients. It will save lives!

The five worst and the five best states of Covid-19 death rates versus percent of population tested:

  1.  Michigan              9.48% death rate and 2.4% of population tested

2.  Connecticut      8,87%                            3.1%

3.  New York          7.80%                            5.6%

4.  Lousiana           7.23%                            4.4%

5.  New Jersey       6.55%                            4.4%

….

46. Tennessee         1.66%                            3.4%

47. Nebraska           1.17%                            2.0%

48. Wyoming           1.08%                            2.1%

49. Utah                    1.03%                            4.3%

50. South Dakota     0.98%                            2.4%

Beside from the obvious fact that the five worst states are all run by Democrat Governors and the five best state are all run by Republicans, these are my observations:

Michigan has a Detroit problem. The COVID-19 death rate there is over 10%, many got turned away from the few hospitals and were sent home without first being tested. Governor Gretchen Whitmer seems more interested in controlling the healthy population than to protect the vulnerable.

Why Connecticut is second on the list I don’t know, but Hartford County has a problem with a death rate over 10%

The problem with New York is that Governor Cuomo ordered nursing home facilities to accept COVID-19 patients, they are not set up to handle highly contagious patients, and so the infection and death rate among the most vulnerable population skyrocketed. One interesting statistics is that two thirds of all New York COVID-19 cases were from people staying home, not going out at all.

The problem with Louisiana is that it let Mardi Gras proceed and people came, did their thing and went back to where they came from, often to under-served areas.

New Jersey is next to New York. Need I say more?

On the other hand, the five best states concentrated their efforts to protect the at risk people, concentrating on hygiene and social distancing rather than trying to micromanage the healthy population. There seem to be no improvement in the outcome by adding testing. In addition the death rate among the five worst states is still rising, whereas the death rate in the five best states is declining.

Governor Kristi Noem of South Dakota, the state with the best outcome so far did order a clinical test of using the combination Hydroxychloroquine + Azithromycin + Zinc for five days and that may be the reason the death rate is less than 1 percent. Unfortunately the FDA is concerned that hydroxychloroquine and chloroquine are being used inappropriately to treat non-hospitalized patients for coronavirus disease (COVID-19) or to prevent that disease.  Quote:” We authorized their temporary use only in hospitalized patients with COVID-19 when clinical trials are not available, or participation is not feasible, through an Emergency Use Authorization (EUA).  These medicines have a number of side effects, including serious heart rhythm problems that can be life-threatening.”

Here is my suggestion: Issue an executive order opening up a clinical study in the effectiveness of COVID-19 treatment with Hydroxychloroquine + Azithromycin + Zinc for five days, and open it up to any qualified Physician or Nurse Practitioner who want to participate. They do the heart test, check for other ailments and report the results to a central data base and a follow up report, and even if it is not a double blind study, once you have a million or so results the FDA can approve the medication. In the meantime over 90% of the patients were getting better, and hopefully nobody had given it to patients with severe preexisting heart conditions. The risk is minimal. It is already approved for Lupus, Rheumatism and Malaria, and the same protocol should apply here.

It is very important the drug is administered as early as possible. By the time the patient is admitted to a hospital it may be too late. Especially if the patient is already on a ventilator it may do more harm than good.

Why is this study even necessary? This medication is too cheap, it is generic, so no pharmaceutical company is willing to foot the bill on something unprofitable, so it must be done by a university or through a government agency.

It is not that daring a thing to do. Here is a result of a COVID-19 study with more than 6,200 physicians in 30 countries.

  • The three most commonly prescribed treatments among COVID-19 treaters are 56% analgesics, 41% Azithromycin, and 33% Hydroxychloroquine
  • Hydroxychloroquine usage among COVID-19 treaters is 72% in Spain, 49% in Italy, 41% in Brazil, 39% in Mexico, 28% in France, 23% in the U.S., 17% in Germany, 16% in Canada, 13% in the UK and 7% in Japan
  • Hydroxychloroquine was overall chosen as the most effective therapy among COVID-19 treaters from a list of 15 options (37% of COVID-19 treaters)
    • 75% in Spain, 53% Italy, 44% in China, 43% in Brazil, 29% in France, 23% in the U.S. and 13% in the U.K.
  • The two most common treatment regimens for Hydroxychloroquine were:
    • (38%) 400mg twice daily on day one; 400 mg daily for five days
    • (26%) 400mg twice daily on day one; 200mg twice daily for four days
  • Outside the U.S., Hydroxychloroquine was equally used for diagnosed patients with mild to severe symptoms whereas in the U.S. it was most commonly used for high risk diagnosed patients
  • Globally, 19% of physicians prescribed or have seen Hydroxychloroquine prophylactically used for high risk patients, and 8% for low risk patients.

And this is a very recent tweet from president Donald Trump, without which frequent and persistent recommendation this drug combination would have already been approved, as it is in at least 12 other countries.

  • Hcq

 

Clinical trials take too long. With the COVID-19 virus acting on a time scale of 3 days, not 3 years, allow unlimited trials now!

The medicine suppliers have to go through a lot to get a new drug approved. There are the double blind tests that can take years to verify, and some of the people in the protocol are given placebos that only produce the side-effects, not the potential cure. Some of these people may die as a result, but that the cost of getting a drug approved. The cost can be upwards of 10 million dollars, so as a reward the Medical supplier company gets awarded a patent for the new medicine. This can take many years to develop, and a patent is valid for only 20 years, so a patent extension of up to 5 years is almost routinely granted. After the patent is expired it becomes a generic drug. And another thing, there has to be at least 170000 people suffering from the disease to make it worthwhile.

There is another way. Over 10 years ago my wife got a case of wet macular degeneration in one eye, but it was not the normal type, more like a blood-filled polyp lodging itself under the retina and causing warped vision to say the least.

There was an approved medication at 2000 dollars an injection, the insurance company paid for it, so she tried it, and it did absolutely nothing. But the eye doctor said, he worked with the Amish community, and they are uninsured and cannot afford more than generic drugs. He had had good results for a few to inject Avastin, an approved drug for colon and rectal cancer among other things, and in the amount needed for injection in one eye the cost was only 70 dollars. The trade-off was obvious; 2000 dollars for a drug that the insurance company paid for, but didn’t work versus a 70 dollar medicine that might work, so she let herself be included in the study. And it worked! And the doctor paid for the cost of the medicine himself, he wanted the study to succeed. He was not alone, a few other doctors worked together to find the cure. A few years later the insurance company accepted the treatment, and my wife’s polyp eventually disappeared.

The point of the story? To rely only on approved medications when confronted with cases out of the ordinary, medical science is advancing not only by medical companies seeking new and profitable drugs, or by University research, but by your regular doctor, in consultation with his peers, as they seek to find the best cure for the individual patient.

The Government is always to slow to react. In the case of COVID-19, it works on a time-scale of 3 days, so the best treatment must be administered immediately, not wait for normal approval procedures. So is the case with Hydroxychloroquine, it is approved and generic, no one will make a case study, the side effects are minimal for Lupus or rheumatic patients, of which there are tens of thousands patients and no one has died from it when applied in approved doses, so administer it to anyone that accepts to be in the study now!

 

 

 

 

The worst pandemic the world has ever seen can be stopped quickly, and this is how.

The pandemic has spread to the whole world, only Tajikistan and North Korea  have yet to report any cases, but territories like Falkland Islands and Saint Pierre Miquelon have reported in, a total of 208 countries and territories as of now. Antarctica is so far spared, but nobody lives there anyhow, only a few thousand people on temporary assignments.

This means the COVID-19 virus is so contagious that it will affect us all, and with a 3 day doubling rate it will not take long until everybody is or has been infected, except for those with protection or immunity.

One possible such protection is the use of Hydroxychloroquine, or just plain Chloroquine Phosphate. These are common drugs to protect against malaria, and in countries where malaria is prevalent there seems to be much fewer cases than in countries without malaria threats. These drugs are safe for most people, but must be taken under advise and prescription from a physician.

Early last week, Dr. Birx in the daily coronavirus briefing promised to look into if there was any correlation between people already taking Hydroxychloroquine for relief from Lupus of Rheumatism and their incidence of contracting COVID-19. She was going to utilize the large, anonymous part of the Medicare and Medicaid database that lists everybody that receives these benefits. It is already used to study interactions between medicines and outcomes, a most valuable resource, but as always they normally take their jolly time to verify and certify the results. She wanted the results by last Friday to keep up with the enemy, the virus. If there is a statistically valid difference between Lupus or Rheumatic patients and the population in general we have our answer! (China have their answer, but they are not telling, presumably to maximize the damage in the rest of the world.) If the result is conclusive, here is the answer,

Step 1. Give the Hydroxychloroquine medication to all patients testing positive for COVID-19.

Step 2. Give the medication to all health care workers coming in contact with COVID-19 patients.

Step 3. Give this medication to all potentially coming in contact with COVID-19 positive people such as police, first responders, the military and so on.

Step 4. Give this medication to all who have been in contact with people having tested positive for COVID-19

Step 5. Make taking this medication a condition for international travel and travel to and from national hot spots.

Step 6. Offer this medication to the rest of the world.

The medicine can be manufactured by the tons if speedy approval is issued by the FDA from sources other than China! This is why President Trump invoked the Defense Production Act!

If we can ramp up this action plan speedily, we should be back to normal life within a month, except most of us will have to take one more medication, (but it is cheap). When the vaccine is approved and available this requirement will go away

 

 

 

Why did the Michigan Governor prohibit promising treatment for COVID-19. A Limerick.

The Governor’s Trump hate in Lansing,

from science advancement distancing.

She would let people die,

valid treatment deny

to stop Donald Trump’s reelecting.

The Detroit News’ Kathy Hoekstra reports that Democratic Gov. Gretchen Whitmer’s Department of Licensing and Regulatory Affairs (LARA) has sent a letter to all physicians and pharmacists in the state warning of “professional consequences” if they prescribe or dispense hydroxychloroquine or chloroquine to treat coronavirus patients. Hoekstra writes that “beyond the rational recommendation against hoarding as production of this medication needs to be ramped up, the letter deviates into open threats of “administrative action” against the licenses of doctors that prescribe hydroxychloroquine.” It also orders pharmacists to “ignore physician orders for this medication.”

There must have been a reason why Governor Gretchen Whitmer issued this threatening letter. She could have heard President Trump being excited about a promising study that offered a remedy, or, which is scary, she believed it was dangerous because a husband and wife ate spoonfuls of aquarium tank cleaner which contained chloroquine phosphate, and one of them died. What made this unbelievable story the news of the day in the mainstream media was the dying man’s words:  “Look, this is what Trump recommended, why don’t we try it?” Little did they know that 2 grams is a deadly dose, but it is perfectly safe to take an appropriate dose under a physician’s supervision. It has been taken safely for over 50 years to combat malaria.

So why was President Trump so excited about the french study he was shown? Here are the results:

This was a non random test of 80 people, and one person died, a 70+ year old woman with underlying conditions. They took a chance on her because she was within hours of probable death anyhow, but she was too far gone. The other 79 recovered.

This is no time for double blind large clinical trials. They sometimes take years to verify, and the enemy, the COVID-19 virus works on a time-frame of 3 days, so the only choice is to work with incomplete and uncertified data.

To make matters a little more complicated, China has stopped export of one of the ingredients in making this medicine, and they are the only source, until we have started up production of our own. We have to do it in days, not weeks.

Why did China stop this medical export? There are at least two possibilities, either they are lying through their teeth about the COVID-19 cases and they need it for their own consumption but didn’t tell us, or, which is even worse, they do want to maximize the damage in the rest of the world.

 

 

Nevada governor Sisolak, in a snit of Trump-hate forbids the use of two promising treatments for covid-19, later recanted. A Limerick.

An intrigue in old Carson City

Gov. Sisolak showing no pity

For his Trump-hate is great

but the virus won’t wait

no time to delay and be snitty.

Nevada’s governor has signed an emergency regulation limiting the use of two anti-malaria drugs to treat coronavirus patients, the same medication that President Donald Trump has touted as possible treatments.

Trump has said that using chloroquine and hydroxychloroquine as treatments for coronavirus could be “one of the biggest game changers in the history of medicine,” and said the drugs had been approved for a long time in the treatment of malaria.
Here is a result from a French non-randomized test. This is no time for randomized tests. They may be scientifically perfect, but they take a long time to complete and are very inefficient. Better save lives now!
U.K. and now India is blocking export of these substances, so we must make our own, and fast. FEMA has appropriated all available stockpiles of  Hydroxychloroquin and is distributing to medical doctors as needed to prevent hoarding.
To be fair, Governor Sisolak in a later tweet indicated  that he will not forbid a licensed medical doctor to administer whatever he/she deems necessary for treatment of a patient, in other words, render his executive order moot. But it  captured the headlines.